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- K. Afsal
- V. V. Banurekha
- N. Meenakshi
- M. Harishankar
- P. Pugalendhi
- C. Sankaranarayanan
- P. Subramanian
- S. Nagini
- J. John
- V. Thamarai
- M. M. Mehra
- Teena Choudhary
- M. S. Giridhar
- Ashwini Jambhalikar
- Gogulapati Supriya
- Gaurav Saxena
- K. V. Shila
- B. Ramesh
- T. K. Pratheek
- Deepak Kumar Sharma
- R. Islam
- A. Kalpana
- S. Ajith Kumar
- K. V. Sriram
- A. S. Laxmiprasad
Journals
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Selvaraj, P.
- Effect of Vitamin D3 on Antimicrobial Peptide Gene Expression in the Neutrophils of Pulmonary Tuberculosis Patients
Abstract Views :279 |
PDF Views:90
Authors
Affiliations
1 Department of Immunology, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chetput, Chennai 600 031, IN
2 Department of Clinical Research, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chetput, Chennai 600 031, IN
3 Institute for Thoracic Medicine, Chetput, Chennai 600 031, IN
1 Department of Immunology, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chetput, Chennai 600 031, IN
2 Department of Clinical Research, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chetput, Chennai 600 031, IN
3 Institute for Thoracic Medicine, Chetput, Chennai 600 031, IN
Source
Current Science, Vol 107, No 2 (2014), Pagination: 259-262Abstract
We studied the effect of 1α 25 dihydroxy vitamin D3 (1α,25(OH)2D3), the active form of vitamin D3, on the expression of cathelicidin (CAMP), defensin-α3 (DEF- α3) and vitamin D receptor (VDR) genes in neutrophils cultured with or without Mycobacterium tuberculosis (Mtb) from pulmonary tuberculosis patients and healthy controls. Vitamin D3 significantly enhanced the CAMP, DEF-α3 and VDR mRNA expression in the neutrophils of both the study groups (P < 0.05). Moreover, significantly upregulated CAMP expression was observed in vitamin D3-treated neutrophils infected with Mtb (P < 0.05) in both the study groups. These findings suggest that vitamin D3 enhances innate immunity by increasing the expression of the CAMP gene, which might inhibit the growth of Mtb at the site of infection.Keywords
Antimicrobial Peptide Genes, Cathelicidin, Neutrophils, Tuberculosis, Vitamin D3.- Effect of 1,25-Dihydroxy Vitamin D3 on Toll-like Receptor Gene Expression in Neutrophils of Pulmonary Tuberculosis
Abstract Views :278 |
PDF Views:95
Authors
Affiliations
1 Department of Immunology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chennai 600 031, IN
2 Institute for Thoracic Medicine, Chetput, Chennai 600 031, IN
1 Department of Immunology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Indian Council of Medical Research, 1, Mayor Sathyamoorthy Road, Chennai 600 031, IN
2 Institute for Thoracic Medicine, Chetput, Chennai 600 031, IN
Source
Current Science, Vol 107, No 4 (2014), Pagination: 642-645Abstract
We studied the effect of 1,25-dihydroxy vitamin D3 [1,25(OH)2D,3] on toll-like receptor (TLR) gene expression in neutrophils cultured with Mycobacterium tuberculosis (Mtb) with or without 1,25(OH)2D3 in pulmonary tuberculosis patients and healthy controls. 1,25(OH)2D3 significantly increased the expression of TLR2, TLR9 and TIRAP genes compared to control cells in both the study groups (P < 0.05). In healthy controls, a significantly upregulated expression of TIRAP was observed in Mtb infected cells cultured with 1,25(OH)2D3 compared to Mtb infected cells alone (P < 0.05). In conclusion, 1,25(OH)2D3 upregulated the expression of TLR and TIRAP genes, which could lead to the activation of TLR signalling pathways and augment the innate immunity to tuberculosis.Keywords
Gene Expression, Neutrophils, Tuberculosis, Toll-like Receptors.- Inspiring Young Minds to Think out of the Box
Abstract Views :278 |
PDF Views:71
Authors
Affiliations
1 Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, IN
1 Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, IN
Source
Current Science, Vol 109, No 10 (2015), Pagination: 1767-1768Abstract
No Abstract.- Instrument for Lunar Seismic Activity Studies on Chandrayaan-2 Lander
Abstract Views :1933 |
PDF Views:105
Authors
J. John
1,
V. Thamarai
1,
M. M. Mehra
1,
Teena Choudhary
1,
M. S. Giridhar
1,
Ashwini Jambhalikar
1,
Gogulapati Supriya
1,
Gaurav Saxena
1,
K. V. Shila
1,
B. Ramesh
1,
T. K. Pratheek
1,
Deepak Kumar Sharma
1,
R. Islam
1,
P. Selvaraj
1,
A. Kalpana
1,
S. Ajith Kumar
1,
K. V. Sriram
1,
A. S. Laxmiprasad
1
Affiliations
1 Laboratory for Electro-Optics Systems, Indian Space Research Organisation, Peenya 1st Stage, 1st Cross, Bengaluru 560 058, IN
1 Laboratory for Electro-Optics Systems, Indian Space Research Organisation, Peenya 1st Stage, 1st Cross, Bengaluru 560 058, IN
Source
Current Science, Vol 118, No 3 (2020), Pagination: 376-382Abstract
Instrument for Lunar Seismic Activity Studies (ILSA) is a science payload with the objective of studying seismic activities at the landing site of Vikram, the Lander of Chandrayaan-2. ILSA will be deployed to the lunar surface by a specially built mechanism. It is an indigenously developed instrument based on microelectro mechanical systems technology. High sensitivity silicon micro-machined accelerometer is the heart of the instrument that measures ground acceleration due to lunar quakes. The instrument has the capability of resolving acceleration better than 100 nano-g Hz–1/2 up to a range of 0.5 g over bandwidth of 40 Hz. This paper presents the basic concepts in the design, realization, characterization and the performance test results of the space qualified strong motion seismic sensors.Keywords
Lunar Quakes, MEMS, Seismometer, Strong Motion Sensors.References
- Bulow, R. C. et al., New events discovered in the Apollo lunar seismic data. J. Geophys. Res., 2005, 110, E10003.
- Yamada, R., The description of Apollo seismic experiments; www.darts.isas.jaxa.jp/planet.seismology.
- Watters, T. R. et al., Shallow seismic activity and young thrust faults on the Moon. Nature Geosci., 2019, 12, 411–417; https://www.nature.com/articles/s41561-019-0362-2.pdf
- Lognonne, P. et al., SEIS: insight’s seismic experiment for internal structure of mars. Space Sci. Rev., 2019, 215, 12; https:// doi.org/10.1007/s11214-018-0574-6
- Measuring seismic activity on Venus: a real challenge; https://www.seis-insight.eu/en/public-2/planetary-seismology/venus
- Hunter, G. et al., Development of a high temperature Venus seismometer and extreme environment testing chamber. International Workshop on Instrumentation for Planetary Missions, 2012.
- Havskov, J. and Alguacil, G., Instrumentation in Earthquake Seismology, Springer, June 2002; doi:10.1007/978-3-319-21314-9, ISBN 1402029683.
- Kumar, S., Design and Fabrication of Micromcahined Silicon Suspensions, Ph D thesis, Imperial College, London, 2007.
- Kempe, V., Inertial MEMS Principles and Practice, Cambridge University Press.
- Kulah, H. et al., Noise analysis and characterization of a sigmadelta capacitive microaccelerometer. IEEE J. Solid-State Circuits, 2006, 41(2), 352–361.
- John, J. et al., Design and fabrication of silicon micro structure for seismometer, ISSS International Conference on Smart Materials, Structures and Systems, Bengaluru, 2014.
- IEEE standard specification format guide and test procedure for linear single axis nongyroscopic accelerometers IEEE Std 1293, 1998 (R2008).